Simulator-C™
Multi-Cohort Trial Design Canvas
Compose your study visually - dose-escalation cohorts gated by DLT review, basket trials with parallel indication arms, adaptive designs, master and umbrella protocols, crossover designs with washout periods - and the engine auto-derives the full study timeline, recomputed live with every change.
What it does
A structured, transparent approach to multi-cohort design.
01
Canvas-Based Composition
Compose your study from simple building blocks - patient cohorts and the review periods that gate them. Dose escalation, basket arms, staggered starts, and washout windows are all expressed by where components sit on the canvas.
02
A Full View of Your Milestones
The complete milestone picture, always current. Cohort-level and study-level milestones - First Patient In through Last Patient Out - are derived from the design itself and update instantly with every change, with nothing to recalculate by hand.
03
Eleven Built-In Templates
Start from the most common designs - from SAD/MAD and 3+3 dose escalation through basket, umbrella, adaptive, and crossover studies - then shape every cohort to your protocol.
The methodology
A structured alternative to the spreadsheet.
Multi-cohort trial design is one of the most demanding spreadsheet workflows in clinical trial planning. Trials are increasingly multi-cohort, yet feasibility teams still model them in spreadsheets that are slow to build, error-prone, and difficult to compare cleanly - every parameter change ripples through dozens of downstream cells. Trial structure is spatial: parallel arms, sequential stages, and staggered starts are far easier to express as positions on a grid than as chains of cell formulas.
Complex Structures, Simple Blocks
Sequential, parallel, gated, and staggered cohorts are expressed simply by where a component sits on the canvas - the structure you see is the structure you get.
No Manual Date Arithmetic
Every cohort-level and study-level milestone is auto-derived and recomputed live on any change. Restructuring a study becomes a design decision, not a rebuilding exercise.
Consistent, Auditable Outputs
Gantt visualisation and a printable specification, produced from a single source of truth - so the numbers in every deliverable agree.
Clean Scenario Comparison
Ask what happens to Last Patient Out if a review period extends, or if a cohort starts one stage later - and compare saved scenarios instead of duplicating spreadsheet tabs.
Because the timeline is derived rather than maintained, restructuring a study becomes a design decision - not a rebuilding exercise.
How it works
From canvas to committed timeline.
Compose on the Canvas
Lay out cohorts, review gates, parallel arms, and staggered starts visually - or start from one of eleven built-in templates and shape it to your protocol.
The Timeline Derives Itself
Every change flows through the whole design instantly. The full study timeline and every cohort and study milestone stay current - nothing to recalculate, nothing to reconcile.
Build the Deliverable In App
Turn the design into a deliverable without leaving the platform - a full view of every milestone, ready for budget, project management, and biostatistics teams. Scenarios save and reload through Aurora Intel™ project storage.
One design, three views
Switch views. The numbers never disagree.
Canvas
The composition view - your study laid out exactly as you designed it, with every cohort, review gate, and parallel arm in place.
Gantt
Cohort enrolment bars and review windows laid out over calendar months - the study timeline as your project managers and sponsors expect to see it.
Specification
A printable specification with the full cohort schedule, pause periods, and chronological timeline events - ready to drop into a protocol synopsis or planning pack.
11
Built-In Templates
From SAD/MAD and 3+3 dose escalation to basket, umbrella, and crossover designs
2
Building Blocks
Patient cohorts and review periods - structure is expressed by position on the canvas
3
Coordinated Views
Canvas, Gantt, and printable specification - one source of truth
All derived dates are computed directly and transparently from the parameters you set. The engine does not make autonomous decisions or override user inputs - it provides structured, auditable outputs grounded in the design as specified. That is the same human-first foundation behind every module in the Aurora Suite™.
Built for
Who uses Simulator-C™
Feasibility & Strategy Teams
Compare candidate designs cleanly during planning - test how gating, staggered starts, and review periods move the study-level milestones before anything is committed.
Clinical Development Teams
Design dose-escalation, basket, umbrella, and adaptive studies visually, with every cohort configured individually and the full timeline derived for you.
Project Managers
Switch to the Gantt view for cohort enrolment bars and review windows over calendar months - and re-plan by moving components, not rebuilding spreadsheets.
Budget & Biostatistics Teams
Work from a deliverable built in the app - the full milestone picture, consistent with what the design team sees.
Ready to see Simulator-C™ in action?
Book a demo and see how Simulator-C™ turns multi-cohort trial design from a spreadsheet exercise into a design decision.